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  • (PDF) Validating New Reagents: Roadmaps Through the Wilderness | George Cembrowski - paarmann.info
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  • Validating New Reagents: Roadmaps Through the Wilderness. Article (PDF Available) in...
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Some of these can be expected to lead to follow-up appointments or further testing and, ultimately, increased financial burden and anxiety for patients. With some assays and some types of reagent changes, the statistical power of a standard lot-to-lot comparison can be reduced.
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Dominate Validating new reagents roadmaps auspices of the backwoods Verification of new lot reagent's suitability is necessary to ensure that results for patients' samples are consistent before and after reagent lot changes. A typical procedure is to measure results of some patients' samples along with quality control QC materials. In this study, the results of patients' samples and QC materials in reagent lot changes were analysed. In addition, the opinion regarding QC target range adjustment along with reagent lot changes was proposed. Patients' sample and QC material results of reagent lot change events involving 61 analytes and eight instrument platforms were analysed. The size of the between-lot differences in the QC data was calculated as multiples of standard deviation SD. This frequency was not affected by the assay principle or the QC material source.
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